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KMID : 1001920070410050283
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Journal of Korean Neurosurgical Society
2007 Volume.41 No. 5 p.283 ~ p.290
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Seizure Control in Patients with Extratemporal Lobe Epilepsy
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Park Seung-Soo
Koh Eun-Jeong
Oh Young-Min
Lee Woo-Jong
Eun Jong-Pil
Choi Ha-Young
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Abstract
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Objective: This study was designed to analyze seizure outcome and to investigate the prognostic factors for predicting seizure outcome according to the preoperative evaluations, surgical procedures, topectomy sites and histopathological findings in patients with extratemporal lobe epilepsy (ETLE).
Methods: This study comprised 63 patients with ETLE who underwent surgery. Preoperative evaluations included semiologic analysis, chronic video-EEG monitoring, and neuroimaging studies. Surgical procedures consisted of topectomy in 51 patients, corpus callosotomy in 9, functional hemispherectomy in 2, and vagus nerve stimulation (VNS) in 1. Histopathological findings were reviewed. Postoperative seizure outcomes were assessed by Engel’s classification at the average follow up period of 66.8 months. Chi-square test was used for statistics.
Results: Total postoperative seizure outcomes were class I in 51 (80%) patients, class II in 6 (10%), class III in 6 (10%). Patients with structural abnormalities on neuroimaging study showed class I in 49 (88%) patients (p<0.05). Patients with focal and regional ictal EEG onset revealed class I in 47 (90%) patients (p<0.05). Semiologic findings, surgical procedures, topectomy sites and histopathological findings did not show statistical correlation with seizure outcome (p>0.05).
Conclusion: A good seizure outcome was obtained in patients with ETLE. The factors for favorable seizure outcome are related to the presence of structural abnormalities on neuroimaging study, and focal and regional ictal EEG onset.
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KEYWORD
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Epilepsy, Partial treatment outcome, Seizure, Prognostic factor
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